Tailoring crystal size distributions for product performance, compaction of paracetamol

Paracetamol crystals often exhibit poor compressibility properties, which results in capping issues. The Particle Size Distribution (PSD) of paracetamol was engineered to improve the crystals. This accomplished by growing presence additives. active pharmaceutical ingredient Phenacetin and impurity 4-chloroacetanalide were used modify crystal properties paracetamol. In solution, phenacetin or molecules adsorb onto faces selectively (110 011) inhibit further growth consequently, is reduced substantially. For controlling PSD crystals, a set cooling crystallization experiments additive designed. According statistical experimental design, rate most effective parameter. when crystallized from controlled less than 3 mol% both These smaller particles increased almost four-fold comparison commercial material. Moreover, tablets prepared for each formulation using direct compaction method. illustrated that higher tablet hardness achieved tailoring size distribution. addition, disintegration time with hardness. Overall, this work presents potential use structurally similar compounds as additives alter mechanical an API.